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healthy

Other Diseases

For patients with advanced cancers, targeted therapies can provide promising new treatment options.

heart

Heart Disease

  Most heart conditions have a genetic association. This is the reason why heart disease runs in families.

  If you are suffering from heart disease then you must be on some medication.

  In all probability you also must have modified your diet and lifestyle too.

  There is a possibility that drugs you are taking may not be working in you. Genetic factors influence the effect of various drugs.

Genes and its impact on commonly prescribed drugs in cardiac conditions

  • 1. Atenolol: Hypertension patient carrying variation in AGT gene may have a smaller decrease in systolic blood pressure when treated with atenolol.

  • 2. Enalapril: If you carry variation in CSE gene may require you to alter the drug dosage to have the desired impact

  • 3. Losartan: If you carry variation in CYP2C9 gene then Losartan may not work in you

  • 4. Metoprolol: If you are carrying variation in CYP2D6 genotype then you may require to alter the dosage of Metoprolol

  • 5. Verapamil: Variation in CACNA1C, KCNIP1, NR1H3 affects the effect of Verapamil

  • 6. Flecainide: Variation in CYP2D6 genotype effects of metabolism of Flecainide and you may require to alter the dosage

  • 7. Digoxin: Variation in ABCB1 gene can alter the effect of Digoxin

Depending on your requirement please choose the following preventive plans.

  • cardioplus

    Ideal for people suffering from heart disease who are on medication.

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Drugs Covered: Atenolol, Benazepril, Enalapril, Imidapril, Losartan, Metoprolol, Timolol, Verapamil,Irbesartan, Clopidogrel, Atorvastatin, Pravastatin, Fluvastatin, , Lovastatin, Rosuvastatin, Simvastatin.

  • cardio

    Ideal for people at high risk to heart disease or patients who are not on active medication

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Customized prevention plan as per your risk profile

  • positive25

    Ideal for people with family history of cardiac conditions who also want to understand risk for other diseases.

    With Hypertension, coronary artery disease, cardiomyopathies it checks the risk of 25 diseases

    Reduce your risk by following nutrigenomics and lifestyle modification

diabeties

Diabetes

  Diabetes is one of the most challenging health problems in India. Incidence of diabetes is increasing and so are its complications.

  Diabetes leads to a reduced life expectancy and quality of life, as well as a greater risk of heart disease, stroke, peripheral neuropathy, renal disease, blindness and amputation

  Genomics testing can help manage your diabetes by extending medical therapies as well as help restore normal glucose metabolism.

  Genomics test from Positive Bioscience can help you in following ways.

  • Knowing the risk: There are more than 30 genes strongly associated with Type 2 Diabetes. Once you know which gene is driving your diabetes you can take preventive actions.

  • Pharmacogenomics : Know whether you are on the right drug or not.Know which antidiabetic will help you the most from the list of all antidiabetic drugs.

    1. Repaglinide: Variation in SLCO1B1 gene can alter the effect of Repaglinide in you.

  • Nutrigenomics: Effect of various food items depend on your genetic profile. Knowing your genetic profile will help you know what to and what not to eat to manage your diabetes

Depending on your requirement please choose the following preventive plans.

  • cardio_plus

    Ideal for people suffering from heart disease who are on medication.

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Drugs Covered: Atenolol, Benazepril, Enalapril, Imidapril, Losartan, Metoprolol, Timolol, Verapamil,Irbesartan, Clopidogrel, Atorvastatin, Pravastatin, Fluvastatin, , Lovastatin, Rosuvastatin, Simvastatin.

  • cardio

    Ideal for people at high risk to heart disease or patients who are not on active medication

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Customized prevention plan as per your risk profile

  • positive25

    Ideal for people with family history of cardiac conditions who also want to understand risk for other diseases.

    With Hypertension, coronary artery disease, cardiomyopathies it checks the risk of 25 diseases

    Reduce your risk by following nutrigenomics and lifestyle modification

hypertension

Hypertension

  Hypertension is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

  Hypertension is the most common risk factor for stroke and myocardial infarction and predisposes affected individuals to heart failure, ventricular arrhythmias, renal failure, blindness, and other serious medical problems.

  Understanding your genetic profile is the first step in treating hypertension because your genetic profile can determine its aggressiveness.

  • Hypertension is 2.4 times more common in people who have two hypertensive parents

  • Your genetic profile also determines how you respond to antihypertensive drugs

    1. Atenolol: Hypertension patient carrying variation in AGT gene may have a smaller decrease in systolic blood pressure when treated with atenolol.

    2. Benazepril: Variation in AGT gene impacts the effect of drug in you.

    3. Imidapril: Variation in AGT gene impacts the effect of drug in you.

    4. Enalapril: If you carry variation in CSE gene it may require you to alter the drug dosage to have the desired impact

    5. Losartan: If you carry variation in CYP2C9 gene then Losartan may not work in you.

    6. Metoprolol: If you are carrying variation in CYP2D6 genotype then you may require to alter the dosage of Metoprolol.

    7. Verapamil: Variation in CACNA1C, KCNIP1, NR1H3 affects the effect of Verapamil.

    8. Timolol: If you carry variation in ADRB1 gene then Timolol alone may not be effective to control your hypertension.

    9. Irbesartan: Variation in EDN1 gene may lead to altered effect in you.

  Genomics tests can help you manage your hypertension in many ways.

  • Knowing the risk: There are more than 50 genes strongly associated with hypertension. Once you know which gene is driving your hypertension you can take preventive actions.

  • Pharmacogenomics: Know whether you are on the right drug or not by checking for impact of your genes on the drugs you are taking with our pharmacogenomics panel.

  • Nutrigenomics: Effect of various food items depend on your genetic profile. Knowing your genetic profile will help you know what to and what not to eat to manage your disease.

Depending on your requirement please choose the following preventive plans.

  • cardio_plus

    Ideal for people suffering from heart disease who are on medication.

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Drugs Covered: Atenolol, Benazepril, Enalapril, Imidapril, Losartan, Metoprolol, Timolol, Verapamil,Irbesartan, Clopidogrel, Atorvastatin, Pravastatin, Fluvastatin, , Lovastatin, Rosuvastatin, Simvastatin.

  • cardio

    Ideal for people at high risk to heart disease or patients who are not on active medication

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Customized prevention plan as per your risk profile

  • positive25

    Ideal for people with family history of cardiac conditions who also want to understand risk for other diseases.

    With Hypertension, coronary artery disease, cardiomyopathies it checks the risk of 25 diseases

    Reduce your risk by following nutrigenomics and lifestyle modification

Psychiatric-Disorders

Psychiatric Disorders

  Mental Disorders: Depression, bipolar disorder, schizophrenia, autism results from the complex interplay of multiple genes with diverse environmental factors. Family studies, often with identical twins who share the same genes, have provided evidence of genetic contributions to these and other mental disorders.

  Understanding your genetic profile is the first step in treating your disease because your genetic profile determines aggressiveness of disease, response to medication and response to food and lifestyle modifications

  Genomics tests can help you manage your disease in following ways.

  • Knowing the risk: Most neurological disease are polygenic and happens because of genetic change. Its very important to understand which genetic change is driving disease in you to better manage the disease.

  • Pharmacogenomics: Your genetic profile also impacts response of various drugs. Our pharmacogenomics panel can help you understand this impact. Genetic profile determines the impact of following commonly used drugs:

    Amphetamine Atomoxetine Clonidine Dextroamphetamine Lisdexamfetamine
    Dexmethylphenidate Methylphenidate Amitriptyline Clomipramine Desipramine
    Doxepin Imipramine Nortriptyline Trimipramine Citalopram
    Escitalopram Duloxetine Paroxetine Sertraline Venlafaxine
    Mephenytoin Valproic Acid Phenytoin Aripiprazole Haloperidol
    Clozapine Olanzapine Risperidone Diazepam Clopidogrel
     
  • Nutrigenomics: Effect of various food items depend on your genetic profile. Knowing your genetic profile will help you know what to and what not to eat to manage your disease.

Depending on your requirement please choose the following preventive plans.

  • neuro_plus

    Ideal for people suffering from Depression, Bipolar, Epilepsy

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    All routinely prescribed drugs covered

  • protect_neuro

    Ideal for people at high risk to neurological disorders or patients who are not on active medication

    Know whether commonly used drugs will work in you or not by checking pharmacogenomics.

    Customized prevention plan as per your risk profile

  • positive25

    Ideal for people with family history of neurological conditions who also want to understand risk for other diseases.

    Along with Depression, Bipolar, Stroke, Epilepsy it tests the risk of 25 diseases

    Reduce your risk by following nutrigenomics and lifestyle modification

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